![Image of a male surgeon in the operating room with royal blue hash pattern overlay](https://d1xvb4xaszdwk1.cloudfront.net/5eb0affe-1991-449b-bfc0-a5a0516548bf/a784649b-4cce-4b18-8d5a-495dd1986ac3/a784649b-4cce-4b18-8d5a-495dd1986ac3_webp_automated_rendition__c.webp)
Cardiac and Vascular Surgeons
Impella 5.5 with SmartAssist and Low Cardiac Output Syndrome (LCOS)
LCOS, a state of cardiogenic shock with a 10% incidence rate, has multiple definitions with a common determination of hemodynamic instability requiring pharmacological or mechanical support.
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Preoperative Considerations for LCOS
Identifying certain risk factors that can contribute to LCOS may inform the decision on treatment options.
Independent Predictors of LCOS Using Stepwise Logistic Regression Analysis
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Selecting the Appropriate MCS Device
Impella 5.5 with SmartAssist delivers full cardiac support with maximum unloading, allowing the heart to rest and recover.
Despite pharmacological support, 10.1% of adults undergoing cardiac surgery develop LCOS.1 LCOS increase the risk of postoperative mortality by 12- to 25-fold.2-6
The emergence of LCOS after cardiac surgery significantly increases length of intensive care unit (ICU) and hospital stay, 30-day readmission rates and costs of treatment.
The occurrence of LCOS after cardiac surgery decreases the rate of hospital discharge to home from 80% to 50%. Moreover, LCOS increases the risk-adjusted hospital cost by an average of $16,000.1
Cardiac Surgery with LCOS | Cardiac Surgery without LCOS | P-Value | |
---|---|---|---|
Risk-adjusted hospital cost | $64K | $48K | <0.001 |
Risk-adjusted length of stay | 10.1 days | 8.5 days | <0.001 |
Risk-adjusted length of ICU stay | 5.5 days | 3.3 days | <0.001 |
Provide myocardial rest | 16.6% | 13.9% | <0.001 |
Discharged home | 50% | 80% | <0.001 |
Impella 5.5 with SmartAssist Clinically Demonstrated Improvement in Overall Survival
![Data from the First 200 Patients Treated](https://d1xvb4xaszdwk1.cloudfront.net/5eb0affe-1991-449b-bfc0-a5a0516548bf/18ce4fb4-5c3a-4995-b32b-2da1b6cbd13a/18ce4fb4-5c3a-4995-b32b-2da1b6cbd13a_webp_automated_rendition__c.webp)
![Data from the First 200 Patients Treated](https://d1xvb4xaszdwk1.cloudfront.net/5eb0affe-1991-449b-bfc0-a5a0516548bf/18ce4fb4-5c3a-4995-b32b-2da1b6cbd13a/18ce4fb4-5c3a-4995-b32b-2da1b6cbd13a_webp_automated_rendition__c.webp)
Data from the First 200 Patients Treated
Survival and Recovery by Indication
![Sustained results in >3,700 patients](https://d1xvb4xaszdwk1.cloudfront.net/5eb0affe-1991-449b-bfc0-a5a0516548bf/77e4ec2c-36c6-4871-a9de-e412a46a1695/77e4ec2c-36c6-4871-a9de-e412a46a1695_webp_automated_rendition__c.webp)
![Sustained results in >3,700 patients](https://d1xvb4xaszdwk1.cloudfront.net/5eb0affe-1991-449b-bfc0-a5a0516548bf/77e4ec2c-36c6-4871-a9de-e412a46a1695/77e4ec2c-36c6-4871-a9de-e412a46a1695_webp_automated_rendition__c.webp)
Sustained results in >3,700 patients
Survival and Recovery by Indication
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References
- Duncan, A. et al. (2022). J Thorac Cardiovasc Surg, 163(5), 1890-1898.e10
- Algarni, K. (2011), Ann Thorac Surg, 92(5), 1678-1684.
- Ding, W., et al. (2015), Int Heart J, 56(2), 144-149.
- Maganti, M., et al. (2005), Circulation, 112(9 suppl), 1448-1452.
- Maganti, M., et al. (2010), J Thorac Cardiovascular Surg, 140(4), 790-796.
- Sa, M., et al. (2012), Rev Bras Circ Cardiovasc, 27(2), 217-223.
NPS-1338